Fuller’s first position was of as a gag cartoonist for the Daily Graphic in the early 1920s. In 1925, he moved to the animation industry and started working as an animator at Bray Productions. However, his career as an animator was short lived and he soon moved back to the press industry. In 1927, he published the newspaper feature, Laffs in News Dispatches, which run until 1929.
In the 1930s, he worked as an editor for the New York Daily Mirror, at the end of the 1930s, he made the daily Elza Poppin’s for the King Features Syndicate, and in the mid-1940s, he briefly worked for DC Comics. He was also the creator of Doc Syke for the New York Evening Sun, which run from 1944 to 1960. Fuller was also writing radio and movie gags.